Harold Raistrick, 1890-1971.

Cxxxi. Studies in the Biochemistry of Micro-organisms

Cviii. Studies in the Biochemistry of Micro-organisms Lviii. Synthesis of Spinulosin (3:6-dihydroxy-4- Methoxy-2:5-toluquinone) a Metabolic Product of Penicillium

Observations on the Structural Formula for Mycophenolic Acid by J. H. Birkinshaw, H. Raistrick

Alsberg & Black (1913) first isolated and named mycophenolic acid, C17H200,6, from culture filtrates of PeniciUlium stoloniferum Thom. The acid was next reported by Clutterbuck, Oxford, Raistrick & Smith (1932) as a metabolic product of twelve species or strains in the P. brevi-compactum series, a series to which P. stoloniferum belongs. Clutterbuck & Raistrick (1933), as the result ofan extens...

Studies in the biochemistry of micro-organisms; dehydrocarolic acid, a metabolic product of Penicillium cinerascens Biourge.

These products are: (a) I-y-Methyltetronic acid. [I, R =-CH3; X= H. Clutterbuck, Raistrick & Reuter, 1935c.] (b) Carolic acid. [II; hydrated form, I, RB=-CH3; X=-CO.CH2.CH2.CH20H. Clutterbuck, Haworth, Raistrick, Smith & Stacey, 1934; Clutterbuck et al. 1935a.] (c) Carolinic acid. [I,R =-CH3;X =-CO. CH2. CH2. COOH. Clutterbuck et al. 1934, 1935a.] (d) Carlic acid. [I, hydrated form, R=-CH2.COOH...

Rna Metabolism in Hela Cells at Reduced Temperature

Incubation of HeLa cells at 24 degrees C results in the modification of the processing of pre-tRNA to tRNA. Both methylation and size reduction were shown to take place in vitro when purified pre-tRNA was subjected to processing in a cytoplasmic extract of HeLa cells The migration of pre-tRNA from the nucleus to the cytoplasm was not significantly altered at 24 degrees C